Prognostic Value of BIM Deletion in EGFR-Mutant NSCLC Patients Treated with EGFR-TKIs: A Meta-Analysis

Table 4

Meta-analysis of BIM deletion polymorphism associated with OS.

Subgroup	No. of studies	BIM deletion/total	(%)	Pooled HR	95% CI
Overall	13	303/1830	43.0	1.22	0.99-1.50	0.068
Country
China	7	187/1133	12.5	1.30	1.06-1.60	0.013
Others	6	116/697	58.1	1.12	0.75-1.69	0.579
HR estimates
Reported	8	216/1255	59.6	1.25	0.90-1.74	0.178
Estimated	5	87/575	0	1.21	0.96-1.53	0.101
Survival analysis
Univariate	11	262/1574	11.0	1.22	1.02-1.45	0.029
Multivariate	2	41/256	89.2	1.47	0.31-6.92	0.622

OS: overall survival; HR: hazard ratio. All HRs were pooled by a random effects model.