Full Genomic Sequences of H5N1 Highly Pathogenic Avian Influenza Virus in Human Autopsy Specimens Reveal Genetic Variability and Adaptive Changes for Growth in MDCK Cell Cultures

<div>Genetic variability and genome signature in the H5N1 viral. (a) Amino acid changes as compared between amino acid sequencing from the autopsy specimens and the virus isolates. (b) The genomic signatures of amino acid residues obtained from an alignment. The graphical presentation was performed using WebLogo. The height of symbol represents the relative frequency and proportion of the amino acid residue corresponding at the particular position. (c) An alignment of the HA1 amino acid sequences. (d) The 3D structure of trimeric HA molecule (PDB code: 3FKU) showing the point mutation position observed in the study.</div>

BioMed Research International

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Figure 1: Full Genomic Sequences of H5N1 Highly Pathogenic Avian Influenza Virus in Human Autopsy Specimens Reveal Genetic Variability and Adaptive Changes for Growth in MDCK Cell Cultures 

Figure 1 | Full Genomic Sequences of H5N1 Highly Pathogenic Avian Influenza Virus in Human Autopsy Specimens Reveal Genetic Variability and Adaptive Changes for Growth in MDCK Cell Cultures 