α-Amylase Inhibitory Activity of Catunaregam spinosa (Thunb.) Tirveng.: In Vitro and In Silico Studies

Table 5

ADMET profiles of selected compounds.

S.N.	Compounds	GI Abs.	P-gp substrate2	BBB permeation	CYP3 inhibition	Hepatotoxicity	Cytotoxicity	Immune toxicity	Toxicity class	Predicted LD50 (mg/kg)
1.	Acarbose	Low	Yes	No	No	—	No	Yes	6	24000
2.	Balanophonin	High	Yes	No	No	No	No	Yes	5	5000
3.	Catunaregin	High	Yes	Yes	Yes (CYP2D6)	No	No	Yes	4	600
4.	β-Sitosterol	Low	No	No	No	No	No	Yes	4	890
5.	Medioresinol	High	Yes	No	Yes (CYP2D6)	No	No	Yes	4	1500
6.	Morindolide	High	No	Yes	No	No	No	No	5	5000
7.	Scopoletin	High	No	Yes	Yes (CYP1A2)	—	No	—	5	3800