Effects of Soft Tissue Closure on Medication-Related Osteonecrosis of the Jaw in a Rabbit Model with Tooth Extraction: A Pilot Study

Table 4

The incidence of osteonecrosis of the control and experimental group on the mandible at week 4 and week 8.

Groups	Control		ZA-treated		value	value
Time point	Week 4	Week 8	Week 4	Week 8
ONJ	2 ()	0	4 ()	4 ()
NON-ONJ	3	5	1	0
	5	5	5	4
Incidence	40%	0%	80%	100%	0.524	0.008
value	—	—	1	—
value	0.444		1

Intergroup comparison of the incidence between control and ZA-treated groups at week 4; intergroup comparison of the incidence between control and ZA-treated groups at week 8, significant difference in the incidence of histological osteonecrosis was detected between control and ZA-treated group; intragroup comparison of the incidence at each time point in each group between left and right sides; intragroup comparison in the control and ZA-treated group.