Design and Optimization of Cationic Nanocapsules for Topical Delivery of Tretinoin: Application of the Box-Behnken Design, In Vitro Evaluation, and Ex Vivo Skin Deposition Study

Table 4

Results of regression analysis for responses (EE%) and (particle size).

	Model		Adjusted	Predicted	Adequate precision	SD	%CV	value
: EE%	Quadratic	0.8202	0.7483	0.6050	9.514	8.33	11.10	0.001
: PS	Linear	0.7928	0.7769	0.7360	13.658	17.54	10.26	<0.0001