Design and Optimization of Cationic Nanocapsules for Topical Delivery of Tretinoin: Application of the Box-Behnken Design, In Vitro Evaluation, and Ex Vivo Skin Deposition Study

Table 9

Mean erythemal scores observed for encapsulated TTN gel (HG-TTN-LCNC), nanocapsule non-TTN gel (HG-LCNC), nonencapsulated TTN gel (HG-TTN), and commercial gel (HG-C) obtained at the end of 24, 48, and 72 h.

Formulation	Erythemal scores ()
	24 h	48 h	72 h
HG-TTN-LCNC	0	0	0
HG-LCNC	0	0	0
HG-TTN	1	1	1
HG-C	1	2	2