Review Article

Effect of Pericytes on Cerebral Microvasculature at Different Time Points of Stroke

Table 2

Changes in pericytes at different time points after cerebral ischemia.

StudiesAnimalsModelIschemia timePericyte-related indicators

Makihara N et al. 2015 [15]Male, wild-type S129 mouse, 20-35 gMCAO (laser-induced photochemical reaction)3 d, 7 d, 14 d, and 21 dPDGFR-β expression: low levels before day 3; increased expression within day 7; after day 14 in all infarcted regions
Liu KF et al. 2001 [16]Male, Sprague-Dawley rats, 300-350 gMCAO (nylon suture)1.5 hSwollen pericytes
Renner O et al. 2003 [17]OF1 mouseMCAO (coagulated by bipolar diathermy)3 h, 12 h, 48 h, 7 d, 12 dPDGFR-β mRNA was specifically upregulated 48 h after ischemia.
Duz B et al. 2007 [18]Male, Sprague-Dawley rats, 200-300 gMCAO (cauterized with a microbipolar unit)1 h, 3 hPericytes and basement membrane separated 1 h after ischemia
Sakuma R et al. 2016 [19]Male, CB-17 mouseMCAO (ligation)3 d, 5 d, 7 dPDGFR β+ pericytes express on day 3 poststroke and start to increase on day 5.
Shibahara T et al. 2020 [20]Male, C57BL/6 mouse, 20-30 gMCAO (laser-induced photochemical reaction)1 d, 7 d, 14 d, 28 dPDGFR β+ pericytes, which rapidly accumulate in 7-14 days and eventually occupy the entire infarcted area within 14 to 28 days
Zhang Y et al. 2020 [21]Male, C57BL/6J mouseMCAO (nylon suture)24 hThe expression of the pericyte marker α-SMA was reduced, and the expression of NG-2 was significantly decreased.
Arimura K et al. 2012 [22]Male, Wistar-Kyoto rats, 360-440 gMCAO (laser-induced photochemical reaction)1 d, 3 d, 5 dThe expression of PDGFR-β in perivascular cells in the peri-infarct area was significantly upregulated within 5 days after MCAO.