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Studies | Animals | Model | Ischemia time | Pericyte-related indicators |
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Makihara N et al. 2015 [15] | Male, wild-type S129 mouse, 20-35 g | MCAO (laser-induced photochemical reaction) | 3 d, 7 d, 14 d, and 21 d | PDGFR-β expression: low levels before day 3; increased expression within day 7; after day 14 in all infarcted regions |
Liu KF et al. 2001 [16] | Male, Sprague-Dawley rats, 300-350 g | MCAO (nylon suture) | 1.5 h | Swollen pericytes |
Renner O et al. 2003 [17] | OF1 mouse | MCAO (coagulated by bipolar diathermy) | 3 h, 12 h, 48 h, 7 d, 12 d | PDGFR-β mRNA was specifically upregulated 48 h after ischemia. |
Duz B et al. 2007 [18] | Male, Sprague-Dawley rats, 200-300 g | MCAO (cauterized with a microbipolar unit) | 1 h, 3 h | Pericytes and basement membrane separated 1 h after ischemia |
Sakuma R et al. 2016 [19] | Male, CB-17 mouse | MCAO (ligation) | 3 d, 5 d, 7 d | PDGFR β+ pericytes express on day 3 poststroke and start to increase on day 5. |
Shibahara T et al. 2020 [20] | Male, C57BL/6 mouse, 20-30 g | MCAO (laser-induced photochemical reaction) | 1 d, 7 d, 14 d, 28 d | PDGFR β+ pericytes, which rapidly accumulate in 7-14 days and eventually occupy the entire infarcted area within 14 to 28 days |
Zhang Y et al. 2020 [21] | Male, C57BL/6J mouse | MCAO (nylon suture) | 24 h | The expression of the pericyte marker α-SMA was reduced, and the expression of NG-2 was significantly decreased. |
Arimura K et al. 2012 [22] | Male, Wistar-Kyoto rats, 360-440 g | MCAO (laser-induced photochemical reaction) | 1 d, 3 d, 5 d | The expression of PDGFR-β in perivascular cells in the peri-infarct area was significantly upregulated within 5 days after MCAO. |
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