Effect of Pericytes on Cerebral Microvasculature at Different Time Points of Stroke

Table 3

Changes in pericytes at different time points of cerebral ischemia-reperfusion in rats.

Studies	Animals	Model	Ischemia time	Reperfusion time	Pericyte-related indicators
Garbuzova-Davis S et al. 2014 [23]	Male, SD rats,  g	MCAO (filament)	60 min	30 d	Disruption of microvascular structure and degeneration of peripapillary cell protrusions in rat motor cortex
Zhai ZY et al. 2019 [24]	Male, SD rats, 280-320 g	MCAO (nylon suture)	90 min	28 d	The expression of α-SMA in the ischemic border zone was not significantly different from sham, and the expression of VEGFR-2 was increased.
Garbuzova-Davis S et al. 2013 [25]	Male, SD rats,  g	MCAO (filament)	60 min	7 d	In the ipsilateral hemisphere of MCAO injury, pericytes degenerate and impair the integrity of the blood-brain barrier.
Shin YJ et al. 2013 [26]	Male, SD rats, 250-300 g	MCAO (nylon suture)	60 min	1 d, 3 d, 7 d, 14 d	The intensity of ipsilateral ischemic brain VEGFR-3 expression was significantly higher 3-7 days after focal cerebral ischemia. At 14 days after reperfusion, no significant expression of VEGFR-3 associated with blood vessels was seen in the ischemic area.
Deguchi K et al. 2014 [27]	Male, Wistar rats, 250-280 g.	MCAO (nylon suture)	90 min	1 d, 4 d, 14 d, 28 d	Coverage of endothelial cells by pericytes in ischemic brain areas decreases briefly and shortly after transient ischemia, then increases, peaks at 4-7 days, and then gradually returns to 28 days and six hours after reperfusion.
Noh JS et al. 2015 [28]	Male, SD rats, 250-300 g	MCAO (nylon suture)	60 min	6 h, 3 d, 7 d, 14 d	G-protein-coupled calcium-sensitive receptors are elevated in the ischemic region, preferentially affecting pericytes.
Han D et al. 2015 [29]	Male, Wistar rats, 250-280 g	MCAO (nylon suture)	120 min	24 h	The pericyte cytosol is swollen and oval in shape, compressing the microvasculature, and the lumen is significantly smaller; the pericyte is partially separated from the basement membrane.
Zhou YF et al. 2018 [30]	Male, SD rats, 300~600 g	MCAO (nylon suture)	2 h	1 d, 3 d, 7 d	PDGFR β+ pericyte coverage increased at 3 and 7 days after MCAO.
Wang F et al. 2020 [31]	Male, SD rats, 250–300 g	MCAO (nylon suture)	1.5 h	14 d	Pericapillary cell coverage plays a key role in maintaining blood-brain barrier integrity, and both PDGFR-β and CD31 expression were significantly reduced.