Research Article

Single-Dose Toxicity Study on ML171, a Selective NOX1 Inhibitor, in Mice

Table 1

Mean bodyweights.

SexGroup/dose (mg/kg)Day
14815

MaleG1/0Mean30.330.831.533.5
SD0.70.70.91.6
5555
G2/0Mean0.230.131.633.4
SD1.22.11.81.8
5555
G3/125Mean30.530.531.433.6
SD1.71.71.81.9
5555
G4/250Mean30.430.231.533.4
SD1.21.412.2
5555
G5/500Mean30.430.833.035.4
SD1.40.21.50.6
5222

FemaleG1/0Mean22.822.924.326.3
SD1.81.32.11.1
5555
G2/0Mean22.922.023.825.8
SD0.90.31.01.7
5555
G3/125Mean22.623.324.626.9
SD1.51.41.91.7
5555
G4/250Mean22.622.424.225.5
SD1.41.11.01.2
5555
G5/500Mean22.922.424.726.2
SD1.42.21.01.6
N5444

G1: negative control; G2: vehicle control. Data represent the , and no significant difference was found in one-way analysis of variance ().