Single-Dose Toxicity Study on ML171, a Selective NOX1 Inhibitor, in Mice

Table 2

Summary of mortality.

Sex	Group/dose (mg/kg)	No. of animals	Day after treatment															Mortality
			1	2	3	4	5	6	7	8	9	10	11	12	13	14	15
Male	G1/0	5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	^#0/5
	G2/0	5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0/5
	G3/125	5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0/5
	G4/250	5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0/5
	G5/500	5	0	0	3	0	0	0	0	0	0	0	0	0	0	0	0	3/5
Female	G1/0	5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0/5
	G2/0	5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0/5
	G3/125	5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0/5
	G4/250	5	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0/5
	G5/500	5	0	0	0	1	0	0	0	0	0	0	0	0	0	0	0	1/5

G1: negative control; G2: vehicle control. Number of dead mice. ^#Number of with mortality/total mice.