Text Mining and Hub Gene Network Analysis of Endometriosis

Figure 3

Uterus tissue-specific network analyses of endometriosis-associated genes by using NetworkAnalyst (http://www.networkanalyst.ca). A total of 100 genes that were mentioned more than 30 times were mapped to the uterus-specific molecular interaction database. The uterus-specific molecular interaction database was collected from the DifferentialNet database (http://netbio.bgu.ac.il/diffnet/). The mapping produced one big subnetwork with several smaller ones. Only subnetworks with at least 3 nodes are shown. The network was trimmed to minimum connected network by reducing less important nodes or edges to avoid too large and dense network. Each colored circle represents a protein interactor participating in the interaction network. The degree of a node is the number of connections it has to other nodes. The node size and color are proportional to the number of the degrees. Nodes with higher degree act as important “hubs” in the network.