Text Mining and Hub Gene Network Analysis of Endometriosis

Table 1

The 20 most significant endometriosis-associated genes.

Gene ID†	Symbol	Description	Frequency‡	value
2796	GNRH1	Gonadotropin releasing hormone 1	859	<0.001
5241	PGR	Progesterone receptor	522	<0.001
7124	TNF	Tumor necrosis factor	480	<0.001
1588	CYP19A1	Cytochrome P450 family 19 subfamily A member 1	446	<0.001
3569	IL6	Interleukin 6	444	<0.001
7422	VEGFA	Vascular endothelial growth factor A	357	<0.001
94025	MUC16	Mucin 16, cell surface associated	350	<0.001
3553	IL1B	Interleukin 1 beta	322	<0.001
2099	ESR1	Estrogen receptor 1	295	<0.001
6046	BRD2	Bromodomain containing 2	254	<0.001
5351	PLOD1	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	231	<0.001
268	AMH	Anti-Mullerian hormone	224	<0.001
4318	MMP9	Matrix metallopeptidase 9	174	<0.001
2069	EREG	Epiregulin	169	<0.001
5743	PTGS2	Prostaglandin-endoperoxide synthase 2	156	<0.001
4313	MMP2	Matrix metallopeptidase 2	144	<0.001
7157	TP53	Tumor protein p53	131	<0.001
5617	PRL	Prolactin	131	<0.001
6347	CCL2	C-C motif chemokine ligand 2	127	<0.001
4790	NFKB1	Nuclear factor kappa B subunit 1	127	<0.001

^†Gene ID: accession number from the ENTREZ gene database. ^‡Frequency: the frequency of each gene being mentioned in endometriosis-associated publications.