β-Sitosterol Alters the Inflammatory Response in CLP Rat Model of Sepsis by Modulation of NFκB Signaling

Figure 3

Measurement of IL-1β (a), IL-6 (b), and IL-10 (c) serum levels using ELISA (/group). Measurements were performed 48 h after surgery in the sham, CLP, DX, and βS groups, and 72 h after surgery in the IMI and IMI+βS groups. All data are normalized to the total protein levels measured by BCA assay ( of , , , , , and in the sham, CLP, DX, βS, IMI, and IMI+βS groups, respectively), and expressed as the . Data were analyzed by ANOVA, followed by Tukey’s post hoc test for sham, CLP, DX, and βS comparison. The IMI and IMI+βS groups were analyzed separately using unpaired -test. ^#Significant difference compared with the sham group (). Significant difference compared with the CLP group (). Significant difference compared with the DX group (). Significant difference compared with the CLP group (). ⁺⁺⁺Significant difference compared with the IMI group (). βS: β-sitosterol; CLP: cecal ligation and puncture; DX: dexamethasone; IMI: imipenem.

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