A Network Pharmacology and Molecular Docking Strategy to Explore Potential Targets and Mechanisms Underlying the Effect of Curcumin on Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus

<div>Workflow of the systematic strategies to elucidate the mechanisms of curcumin in the treatment of SLE-ONFH. ① Acquisition of drugs and disease targets. ② Collection of curcumin targets for the treatment of SLE-ONFH. ③ Analysis of therapeutic target proteins. ④ Topology of analysis of therapeutic targets. ⑤ The construction of curcumin target network, SLE-ONFH target network, and curcumin-SLE-ONFH target protein-protein interaction (PPI) network. ⑥ GO and KEGG enrichment analysis. ⑦ Gene-pathway network analysis. ⑧ Molecular docking.</div>

BioMed Research International

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Figure 1: A Network Pharmacology and Molecular Docking Strategy to Explore Potential Targets and Mechanisms Underlying the Effect of Curcumin on Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus 

Figure 1 | A Network Pharmacology and Molecular Docking Strategy to Explore Potential Targets and Mechanisms Underlying the Effect of Curcumin on Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus 