Marker Genes Change of Synovial Fibroblasts in Rheumatoid Arthritis Patients

Figure 2

RA-related principal component genes were screened based on single-cell sequencing. (a) Quality control of synovial fibroblasts in RA. There were 31654 genes in 384 cells. RA: rheumatoid arthritis; OA: osteoarthritis. (b) The depth of sequencing was significantly correlated with the number of genes detected. Pearson’s correlation coefficient was 0.68. (c) The variance diagram of gene expression for all fibroblast. The red dots represent 2000 highly variable genes, and the black dots represent nonvariable genes. (d) PCA demonstrates significant separations of cells between RA and OA. PC: principal components; RA: rheumatoid arthritis; OA: osteoarthritis. (e) PCA identified the 13 significant PCs. PC: principal components.

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