Marker Genes Change of Synovial Fibroblasts in Rheumatoid Arthritis Patients

Figure 3

Identification of four cell subpopulations for fibroblast. (a) The UMAP algorithm reduced the dimensionality of 13 PCs and clustered into four cell clusters. UMAP: uniform manifold approximation and projection. (b) The cell clusters were matched to the sample types for RA or OA. RA: rheumatoid arthritis; OA: osteoarthritis; UMAP: uniform manifold approximation and projection. (c) Differential analysis identified 1561 gene markers. The top six gene markers for each cell cluster were listed on the left of heatmap. The colors from purple to yellow indicate the gene expression levels in each cell sample from low to high. (d) The expression of genes was matched to the sample types for RA or OA. RA: rheumatoid arthritis; OA: osteoarthritis. The colors from purple to yellow indicate the gene expression levels in each cell sample from low to high. (e) All clusters of cells were annotated according to the scores of singleR. The colors from blue to yellow indicate the gene expression levels from low to high.

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