BEZ235 Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Inhibiting PI3K/AKT/mTOR and Inducing Autophagy

<div>BEZ235 blocked the activation of the PI3K/mTOR pathway induced by sorafenib. (a) Sorafenib (4 <i>μ</i>M) activated the PI3K/AKT/mTOR pathway in Huh7 and Huh7<sup>R</sup> cells. (b) BEZ235 countered the abnormal activation of the PI3K/AKT/mTOR pathway induced by sorafenib. 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SFB: sorafenib; BEZ: BEZ235; SFB + BEZ: sorafenib combined with BEZ235.</div>

BioMed Research International

fig6

Figure 6

Figure 6: BEZ235 Increases the Sensitivity of Hepatocellular Carcinoma to Sorafenib by Inhibiting PI3K/AKT/mTOR and Inducing Autophagy 