Research Article
Iron Status in Newly Diagnosed β-Thalassemia Major: High Rate of Iron Status due to Erythropoiesis Drive
Table 2
A comparison of iron regulation in normal, untranfused, and transfused β-thalassemia major.
| Condition | Erythropoiesis | GDF15 | Hepcidin | Iron absorption |
| Normal | Normal | Normal | Increases when the iron body level increases or with inflammation | Decreases | Decreases with iron deficiency or hypoxia | Increases | Untranfused β-thalassemia major | Increased IE | Increases | Decreases | Increases | Transfused β-thalassemia major (regular transfusion) | Decreased IE | Decreases | Increases | Decreases |
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GDF15 = growth differentiation factor 15; IE = ineffective erythropoiesis.
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