Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta

<div>Effects of GPS on the vasorelaxation of thoracic aortic rings. (a) Chemical structure of GPS. (b) Direct effects of GPS (5, 10, 20, 40, 80, 160, and 320 <i>μΜ</i>) on the thoracic aorta tension. (c) Cumulative concentration-response curves of GPS (5, 10, 20, 40, 80, 160, and 320 <i>μΜ</i>) on endothelium-intact (E+) and endothelium-denuded (E-) aortic rings precontracted with 1 <i>μ</i>M PE or (d) 60 mM KCl. 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BioMed Research International

fig1

Figure 1

Figure 1: Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta 

Figure 1 | Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta 