Expression Pattern and Prognostic Value of EPHA/EFNA in Breast Cancer by Bioinformatics Analysis: Revealing Its Importance in Chemotherapy

Table 2

Prognostic values of EPHA/EFNA mRNA expression for RFS in different BrCa intrinsic subtypes.

Subclasses		HR (95% CI)
EPHA1
Basal like	618	0.61 (0.48–0.79)	0.0001
Luminal A	1,933	0.63 (0.53–0.75)	<0.0001
Luminal B	1,149	0.63 (0.52–0.76)	<0.0001
HER2 positive	251	0.55 (0.37–0.8)	0.0019
EPHA2
Basal like	618	0.84 (0.65–1.09)	0.19
Luminal A	1,933	0.61 (0.51–0.72)	<0.0001
Luminal B	1,149	0.76 (0.63–0.93)	0.0067
HER2 positive	251	0.669 (0.42-1.03)	0.068
EPHA3
Basal like	618	0.85 (0.65–1.11)	0.23
Luminal A	1,933	0.73 (0.61–0.87)	0.00046
Luminal B	1,149	1.21 (0.96–1.52)	0.1
HER2 positive	251	0.74 (0.5–1.08)	0.11
EPHA4
Basal like	360	0.69 (0.49–0.96)	0.029
Luminal A	841	0.69 (0.54–0.88)	0.0026
Luminal B	407	0.57 (0.42–0.79)	0.00047
HER2 positive	156	0.74 (0.46–1.18)	0.21
EPHA5
Basal like	360	0.45 (0.29–0.68)	0.00015
Luminal A	841	0.77 (0.59–1.01)	0.059
Luminal B	407	0.66 (0.48–0.89)	0.0068
HER2 positive	156	0.74 (0.46–1.19)	0.21
EPHA6
Basal like	360	0.78 (0.53–1.15)	0.21
Luminal A	841	1.18 (0.91–1.52)	0.21
Luminal B	407	0.61 (0.45–0.85)	0.0026
HER2 positive	156	0.53 (0.29–0.94)	0.028
EPHA7
Basal like	360	0.68 (0.49–0.95)	0.022
Luminal A	841	1.49 (1.16–1.91)	0.0016
Luminal B	407	0.84 (0.61–1.15)	0.27
HER2 positive	156	2.32 (1.45–3.72)	0.00031
EPHA10
Basal like	360	0.71 (0.49–1.02)	0.064
Luminal A	841	0.54 (0.42–0.7)	<0.0001
Luminal B	407	0.55 (0.4–0.75)	0.00012
HER2 positive	156	1.28 (0.75–2.2)	0.37
EFNA1
Basal like	618	1.36 (1.06–1.76)	0.016
Luminal A	1,933	0.89 (0.73–1.07)	0.21
Luminal B	1,149	1.38 (1.09–1.75)	0.0065
HER2 positive	251	1.45 (0.91–2.33)	0.12
EFNA3
Basal like	618	1.29 (0.97–1.73)	0.082
Luminal A	1,933	0.81 (0.68–0.96)	0.017
Luminal B	1,149	1.39 (1.1–1.76)	0.0057
HER2 positive	251	1.43 (0.96–2.14)	0.081
EFNA4
Basal like	618	1.53 (1.16–2.01)	0.0022
Luminal A	1,933	0.72 (0.6–0.86)	0.00036
Luminal B	1,149	1.29 (1.05–1.6)	0.016
HER2 positive	251	0.82 (0.51–1.3)	0.39
EFNA5
Basal like	618	0.69 (0.54–0.89)	0.0037
Luminal A	1,933	0.61 (0.51–0.73)	<0.0001
Luminal B	1,149	0.67 (0.55–0.83)	0.00015
HER2 positive	251	0.66 (0.45–0.97)	0.033