Prognostic Value of Blood Urea Nitrogen/Creatinine Ratio for Septic Shock: An Analysis of the MIMIC-III Clinical Database

Table 2

HRs (95% CIs) for all-cause mortality across groups of BCR.

Variables	Nonadjusted			Model I			Model II
	HR	95% CI	value	HR	95% CI	value	HR	95% CI	value
28-day all-cause mortality
BCR	1.011	1.006-1.016	<0.001	1.009	1.004-1.014	<0.001	1.007	1.002-1.013	0.013
Tertiles
<16.3	Reference			Reference			Reference
≥16.3, <24.3	1.032	0.875-1.218	0.708	0.911	0.768-1.081	0.286	0.990	0.827-1.186	0.913
≥24.3	1.390	1.190-1.624	<0.001	1.220	1.037-1.436	0.016	1.186	0.993-1.416	0.060
for trend	<0.0001			<0.0001			<0.0001
Quartiles
<14.4	Reference			Reference			Reference
≥14.4, <20.0	0.937	0.769-1.141	0.516	0.842	0.688-1.031	0.096	0.969	0.785-1.195	0.766
≥20.0, <27.3	0.996	0.828-1.198	0.969	0.862	0.710-1.042	0.124	0.942	0.767-1.157	0.571
≥27.3	1.485	1.246-1.769	<0.001	1.281	1.066-1.540	0.008	1.268	1.037-1.551	0.021
for trend	<0.0001			<0.0001			<0.0001
Quintiles
<13.3	Reference			Reference			Reference
≥13.3, <17.7	0.810	0.652-1.004	0.055	0.744	0.597-0.928	0.009	0.903	0.718-1.136	0.385
≥17.7, <22.5	0.911	0.738-1.124	0.385	0.775	0.623-0.963	0.022	0.996	0.791-1.253	0.970
≥22.5, <30.0	1.036	0.846-1.270	0.731	0.879	0.711-1.087	0.233	0.921	0.733-1.156	0.477
≥30.0	1.403	1.158-1.699	<0.001	1.203	0.984-1.471	0.071	1.247	1.002-1.552	0.047
for trend	<0.0001			<0.0001			<0.0001
90-day all-cause mortality
BCR	1.013	1.009-1.017	<0.001	1.012	1.008-1.016	<0.001	1.009	1.005-1.014	<0.001
Tertiles
<16.3	Reference			Reference			Reference
≥16.3, <24.3	1.026	0.886-1.189	0.729	0.913	0.784-1.063	0.241	0.981	0.836-1.151	0.812
≥24.3	1.452	1.265-1.666	<0.001	1.285	1.113-1.484	<0.001	1.240	1.060-1.450	0.007
for trend	<0.0001			<0.0001			<0.0001
Quartiles
<14.4	Reference			Reference			Reference
≥14.4, <20.0	0.939	0.787-1.119	0.481	0.858	0.716-1.028	0.097	0.969	0.804-1.167	0.738
≥20.0, <27.3	1.036	0.880-1.221	0.670	0.904	0.763-1.073	0.249	0.984	0.821-1.179	0.856
≥27.3	1.575	1.347-1.841	<0.001	1.385	1.175-1.633	<0.001	1.344	1.124-1.606	0.001
for trend	<0.0001			<0.0001			<0.0001
Quintiles
<13.3	Reference			Reference			Reference
≥13.3, <17.7	0.853	0.705-1.033	0.104	0.797	0.655-0.969	0.023	0.942	0.770-1.153	0.564
≥17.7, <22.5	0.906	0.750-1.095	0.308	0.784	0.644-0.954	0.015	0.977	0.796-1.200	0.824
≥22.5, <30.0	1.073	0.894-1.288	0.447	0.921	0.761-1.115	0.400	0.967	0.789-1.184	0.742
≥30.0	1.552	1.309-1.841	<0.001	1.358	1.135-1.626	<0.001	1.377	1.134-1.671	0.001
for trend	<0.0001			<0.0001			<0.0001
365-day all-cause mortality
BCR	1.012	1.009-1.016	<0.001	1.010	1.007-1.014	<0.001	1.008	1.004-1.013	<0.001
Tertiles
<16.3	Reference			Reference			Reference
≥16.3, <24.3	1.002	0.894-1.168	0.749	0.899	0.782-1.032	0.131	0.956	0.827-1.105	0.541
≥24.3	1.415	1.247-1.606	<0.001	1.243	1.089-1.148	<0.001	1.212	1.051-1.397	0.008
for trend	<0.0001			<0.0001			<0.0001
Quartiles
<14.4	Reference			Reference			Reference
≥14.4, <20.0	0.938	0.800-1.100	0.432	0.848	0.721-1.000	0.049	0.957	0.810-1.133	0.616
≥20.0, <27.3	1.011	0.872-1.174	0.881	0.874	0.748-1.021	0.089	0.945	0.802-1.112	0.494
≥27.3	1.526	1.323-1.761	<0.001	1.324	1.139-1.540	<0.001	1.309	1.113-1.540	0.001
for trend	<0.0001			<0.0001			<0.0001
Quintiles
<13.3	Reference			Reference			Reference
≥13.3, <17.7	0.865	0.728-1.029	0.102	0.795	0.666-0.950	0.012	0.928	0.773-1.114	0.422
≥17.7, <22.5	0.934	0.786-1.106	0.423	0.797	0.667-0.952	0.013	0.975	0.810-1.172	0.784
≥22.5, <30.0	1.029	0.870-1.217	0.737	0.869	0.728-1.036	0.118	0.905	0.752-1.089	0.291
≥30.0	1.535	1.312-1.796	<0.001	1.326	1.124-1.564	<0.001	1.364	1.143-1.628	<0.001
for trend	<0.0001			<0.0001			<0.0001

HR: hazard ratio; CI: confidence interval. Models were derived from Cox proportional hazards regression models. Nonadjusted model adjusted for none. Adjust I model adjusted for age, sex, race, marital status, and insurance status. Adjust II model adjusted for age, sex, Elixhauser score, RRT use, mechanical ventilation use, chronic pulmonary, CHF, diabetes, fluid electrolyte, liver disease, renal failure, temperature, heart rate, hematocrit, platelets, glucose, SOFA score, MBP, SpO₂, PT, lactate, albumin, bicarbonate, bilirubin, potassium, and calcium.