NaHS Alleviated Cell Apoptosis and Mitochondrial Dysfunction in Remote Lung Tissue after Renal Ischemia and Reperfusion via Nrf2 Activation-Mediated NLRP3 Pathway Inhibition

Figure 8

Sodium hydrosulfide hydrate (NaHS) improved lung injury, the wet/dry weight ratio, PaO₂/FiO₂ ratio, cell counts, neutrophil counts, neutrophil elastase activity, and protein concentration of bronchoalveolar lavage fluid (BALF) in the lung tissue after renal ischemia reperfusion (RIR) in wild-type (WT) and NF-E2-related factor 2 knockout (Nrf2^-/-) mice. Lung tissues were stained with H&E ((a), ×400), and the H&E staining scores in lung tissue were counted (b). The wet/dry weight ratio (c) and PaO₂/FiO₂ ratio of lung tissue (d) are shown as a bar graph. Cell counts (e), neutrophil counts (f), neutrophil elastase activity (g), and protein concentration (h) of BALF are shown as a bar graph. Values are presented as the . vs. the RIR+NaHS-WT+ group; ^# vs. the RIR+NaHS+WT+ group; ^& vs. the IR+NaHS+Nrf2^-/- group; .

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