Cilengitide Inhibits Neovascularization in a Rabbit Abdominal Aortic Plaque Model by Impairing the VEGF Signaling

Table 4

Comparison of changes in the degrees of aortic plaque size and eccentricity index (EI) after cilengitide treatment in the three groups.

	Number of plaques	CGG (point)	Changes in plaque size and EI detected by CUS			Changes in plaque size and EI detected by CEUS
			LD (mm)	AD (mm)	EI	LD (mm)	AD (mm)	EI
T0 group	3
T1 group	5
T2 group	7

Data are presented as . ^#T1 group compared with T0 group; T2 group compared with T0 group; ^&T2 group compared with T1 group; , . CGG: contrast agent grayscale (replace the grayscale with the number of the microbubbles shown in a plaque); LD: longitudinal diameter; AD: anteroposterior diameter; EI: eccentricity index; CUS: conventional ultrasound; CEUS: contrast-enhanced ultrasound. Plaques in the same site were measured for changes in LD, AD, and EI before and after treatment; Negative and positive values for LD and AD indicate that the plaques became smaller or larger after treatment, respectively; Negative and positive values for the EI reflected an increase or decrease of the lumen of the blood vessel.