Overexpression of Long Noncoding RNA H19 Downregulates miR-140-5p and Activates PI3K/AKT Signaling Pathway to Promote Invasion, Migration and Epithelial-Mesenchymal Transition of Ovarian Cancer Cells

Figure 4

Effects of miR-140-5p on OC cells. (a) MiR-140-5p expression level in OC cells and normal ovarian epithelial cells, represents compared with A2780; ^# represents compared with HO-8910; ^@ represents compared with Anglne; ^& represents compared with NIH : OVCAR-3. (b) Proliferation of A2780 and Anglne cells after miR-140-5p transfection. (c) Apoptosis rate and flow cytometry of A2780 and Anglne cells after miR-140-5p transfection. (d) Invasion of A2780 and Anglne cells after miR-140-5p transfection. (e) Migration of A2780 and Anglne cells after miR-140-5p transfection. Western blotting of A2780 and Anglne cells and relative expression levels of proteins in A2780 cells after miR-140-5p transfection. represents compared with miR-140-5p-mimics group; ^# represents compared with the miR-140-5p-inhibition group.

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