Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy

<div>QUE regulates the ECM metabolic balance via autophagy in TBHP-treated NPCs. (a) Western blot analysis of the ECM components, collagen II and ACAN, and the degrading enzyme, MMP13. (b) Quantification of collagen II, ACAN, and MMP13 protein levels. (c, d) Representative images showing immunofluorescence staining for collagen II and MMP13 (collagen II: Alexa Fluor®488 labeled secondary antibody; MMP13: Alexa Fluor®594 labeled secondary antibody, original magnification ×200, scale bar: 75 <i>μ</i>m). (e, f) Semiquantitative analysis of collagen II and MMP13 immunofluorescence staining. 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BioMed Research International

fig5

Figure 5

Figure 5: Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy 