The Combination of Shear Wave Elastography and Platelet Counts Can Effectively Predict High-Risk Varices in Patients with Hepatitis B-Related Cirrhosis

Table 3

The combination of liver stiffness and platelet counts for ruling out and ruling in high-risk varices in patients with hepatitis B-related cirrhosis.

Patients with hepatitis B-related cirrhosis ()
Noninvasive tests	^‡ and	^§ and	Combined rule in/out criteria
Sensitivity	0.96 (0.80-1.00)	0.54 (0.34-0.73)	0.93 (0.66-1.00)
Specificity	0.80 (0.72-0.86)	0.98 (0.93-0.99)	0.97 (0.92-0.99)
PPV	0.48 (0.34-0.62)	0.82 (0.56-0.95)	0.82 (0.56-0.95)
NPV	0.99 (0.95-1.00)	0.92 (0.85-0.95)	0.99 (0.95-1.00)
Positive LR	4.8 (3.4-6.7)	24.1 (7.4-77.8)	34.2 (11.1-105.3)
Negative LR	0.05 (0.01-0.3)	0.5 (0.3-0.7)	0.009 (0.001-0.07)
Spared endoscopies	108/160 (0.68)	17/160 (0.11)	125/160 (0.78)
HRVs missed	1/108 (0.01)	3/17 (0.18)	4/125 (0.03)

Note: data in parentheses are 95% confidence intervals. ^‡Combined criteria for ruling out patients with HRVs. ^§Combined criteria for ruling in patients with HRVs. Abbreviations: HRVs: high-risk varices; LS: liver stiffness; kPa: kilopascal; PPV: positive predictive value; NPV: negative predictive value; LR: likelihood ratio.