Minimally Invasive Embedding of Saturated MSU Induces Persistent Gouty Arthritis in Modified Rat Model

Figure 4

Inflammatory cell infiltration and deposition of MSU in synovial tissue. Representative images of pathological section showed a progressive MSU-mediated inflammation. (a) Top, in the sham groups, the synovial inflammation and disordered collagenous fibers were observed. Bottom, MSU deposited in tissues mediating the immune response and recruiting a large number of inflammatory cells. MSU deposition was surrounded by the inflammatory cells and collagen fibers. (b, c) Large-scale images of MSU deposition surrounded by inflammatory cells in MSU groups received 4-5x interventions. Deposition of MSU was mainly surrounded by lobulated neutrophils. Scale bars, 50 μm.

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