Tumor Microenvironment Subtypes and Immune-Related Signatures for the Prognosis of Breast Cancer

Figure 3

Contributing mechanisms of differential TME phenotypes. A total of 664 significant differentially expressed genes (DEGs) identified through differential analysis with 233 genes upregulated (red) and 431 genes downregulated (blue), respectively (a). DEGs were distributed evenly among three TME subtypes (b). GO analysis (c), KEGG pathways analysis (d), and GSEA (e) were successively carried out, and PPI networks were constructed to explore the interactions (f).

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