Clinical Efficacy and Safety of Zoledronic Acid Combined with PVP/PKP in the Treatment of Osteoporotic Vertebral Compression Fracture: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of all the trials included in the meta-analysis.

Study	Country	Sample size		Age (years)		Interventions		ZA dose and timing	General treatments
		E	C	E	C	E	C
Liu et al. (2017)	China	52	52			PKP+ZA	PKP	5 mg/100 ml, <15 min 2 days after the operation	Rifampicin tablets,120 mg, oral; dexamethasone, 5 mg, injection; before ZA
Zheng et al. (2019)	China	54	48			PKP+ZA	PKP+physiological saline	5 mg/100 ml 1 day after the operation	Calcium carbonate, 750 mg/d, oral; calcitriol, 0.4 μg/d, oral; pre- and postoperation
Hu et al. (2020)	China	121	121			PVP+ZA	PVP	5 mg/100 ml 2 days prior to the operation	Calcium carbonate/vitamin D3 tablets, 600 mg/d, oral; pre- and postoperation
Zhang et al. (2019)	China	50	51			PKP+ZA	PKP	5 mg/100 ml, >15 min 2 days prior to the operation	Calcium carbonate, 3600 mg/d, oral; calcitriol, 0.25 μg/d, oral; 1 year after the operation
Huang et al. (2019)	China	30	30			PKP+ZA	PKP	5 mg/100 ml 3 days after the operation	Calcium, 600 mg/2 d, oral; postoperation
Xuan et al. (2017)	China	40	40			PKP+ZA	PKP	5 mg/100 ml, 1 day after the operation	Calcium, 600 mg/d, oral; calcitriol, 0.25 μg/d, oral; 1 year after the operation
Yan et al. (2014)	China	120	120	ND		PVP+ZA	PVP	5 mg/100 ml, 3 days after the operation	Calcium carbonate/vitamin D3 tablets, 600 mg/d, oral; 6 months after the operation

E: experimental group; C: control group; ND: the study did not report this information.