Ginkgo Biloba Extract EGB761 Ameliorates the Extracellular Matrix Accumulation and Mesenchymal Transformation of Renal Tubules in Diabetic Kidney Disease by Inhibiting Endoplasmic Reticulum Stress

<div>EGB761 reduced the accumulation of ECM and the expression of EMT markers in HK-2 cells via the inhibition of ERS. (a) Western blot of <i>α</i>-SMA and E-cadherin. (b) Bar graph representing the quantification of <i>α</i>-SMA, and bar graph representing the quantification of <i>α</i>-SMA and E-cadherin. (b) The mRNA expression of <i>α</i>-SMA and E-cadherin. (c) Western blot of collagen IV, fibronectin, and bar graph representing the quantification of collagen IV and fibronectin. (d) The mRNA expression of collagen IV and fibronectin. Ctrl: control treated with PBS; TM: tunicamycin; TM+4-PBA: tunicamycin+4-PBA; TM + MD: tunicamycin+EGB761 20 mg/L. 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BioMed Research International

fig5

Figure 5

Figure 5: Ginkgo Biloba Extract EGB761 Ameliorates the Extracellular Matrix Accumulation and Mesenchymal Transformation of Renal Tubules in Diabetic Kidney Disease by Inhibiting Endoplasmic Reticulum Stress 

Figure 5 | Ginkgo Biloba Extract EGB761 Ameliorates the Extracellular Matrix Accumulation and Mesenchymal Transformation of Renal Tubules in Diabetic Kidney Disease by Inhibiting Endoplasmic Reticulum Stress 