Molecular Targets and Associated Signaling Pathways of Jingshu Granules in Ovarian Cysts Based on Systemic Pharmacological Analysis

Table 3

All enriched KEGG signaling pathways of intersection targets between Jingshu granules and ovarian cysts.

Term	value	Genes
Neuroactive ligand-receptor interaction		OPRM1, DRD1, DRD2, GABRA5, NR3C1, CHRM5, HTR1B, ADRB2, ADRB1, CHRM4, CHRM3, GRIA2, CHRM2, CHRM1, F2, ADRA1B, ADRA1A, ADRA2C, ADRA2B, ADRA1D, HTR2A
Calcium signaling pathway		EGFR, DRD1, CHRM5, ADRB2, ADRB1, CHRM3, CHRM2, CHRM1, ADRA1B, ADRA1A, NOS3, PRKACA, NOS2, PPP3CA, ADRA1D, HTR2A
Focal adhesion	0.002679	EGFR, MAPK1, JUN, GSK3B, BCL2, MET, VEGFA, COL3A1, MAPK8, COL1A1, EGF, KDR
Cytokine-cytokine receptor interaction	0.04291	EGFR, IL6, TNF, CCL2, MET, VEGFA, IFNG, IL1B, EGF, KDR, IL2
MAPK signaling pathway	0.047776	EGFR, MAPK1, TNF, MAPK14, JUN, TP53, IL1B, MAPK8, PRKACA, PPP3CA, EGF
Gap junction		EGFR, CDK1, MAPK1, DRD1, ADRB1, DRD2, GJA1, PRKACA, EGF, HTR2A
T cell receptor signaling pathway	0.001614	MAPK1, TNF, MAPK14, JUN, GSK3B, IFNG, PPP3CA, CDK4, IL2
NOD-like receptor signaling pathway		MAPK1, IL6, TNF, CCL2, MAPK14, IL1B, MAPK8, CASP1
Progesterone-mediated oocyte maturation	0.001846	PGR, CDK1, MAPK1, MAPK14, MAPK8, PRKACA, CCNA2, CDK2
Cell cycle	0.014242	CDK1, GSK3B, TP53, CHEK1, RB1, CDK4, CCNA2, CDK2
Drug metabolism	0.001617	GSTM1, CYP3A4, CYP2B6, MAOA, MAOB, CYP1A2, GSTP1
Complement and coagulation cascades	0.002808	PLAT, F10, THBD, F3, F2, F7, PLAU
VEGF signaling pathway	0.004269	MAPK1, PTGS2, MAPK14, VEGFA, NOS3, PPP3CA, KDR
Apoptosis	0.008778	TNF, BCL2, CASP7, TP53, IL1B, PRKACA, PPP3CA
GnRH signaling pathway	0.015262	EGFR, MAPK1, MAPK14, JUN, MAPK8, PRKACA, MMP2
Toll-like receptor signaling pathway	0.017491	MAPK1, IL6, TNF, MAPK14, JUN, IL1B, MAPK8
Oocyte meiosis	0.025501	PGR, CDK1, MAPK1, AR, PRKACA, PPP3CA, CDK2
Neurotrophin signaling pathway	0.042293	MAPK1, MAPK14, JUN, GSK3B, BCL2, TP53, MAPK8
Arginine and proline metabolism	0.004458	ODC1, GOT1, MAOA, MAOB, NOS3, NOS2
Arachidonic acid metabolism	0.005652	AKR1C3, PTGS2, CYP2B6, PTGS1, LTA4H, ALOX5
Metabolism of xenobiotics by cytochrome P450	0.007574	GSTM1, AKR1C3, CYP3A4, CYP2B6, CYP1A2, GSTP1
Glioma	0.009285	EGFR, MAPK1, TP53, RB1, EGF, CDK4
ErbB signaling pathway	0.033168	EGFR, MAPK1, JUN, GSK3B, MAPK8, EGF
p53 signaling pathway	0.049093	CDK1, TP53, CHEK1, CDK4, CDK2
Tryptophan metabolism	0.048697	MAOA, MAOB, CYP1A2, CAT