Correlation between TNF-α -308 and +489 Gene Polymorphism and Acute Exacerbation of Chronic Obstructive Pulmonary Diseases

Table 4

Comparison of the different indicators for the GG genotype and non-GG genotypes.

Group	No. of samples	Frequency of acute exacerbations		Cough or dyspnea (frequency)
		Once/year	>twice/year	Cough	Dyspnea
TNF-α-308
GG	173	153	20	105	68
Non-GG	25	11	14	8	17
value		0.001		0.007
TNF-α +489
GG	116	93	23	14	102
Non-GG	82	60	22	27	55
value		0.324		0.001