Emodin Attenuated the Kidney Damage of High-Fat-Diet Mice via the Upregulation of Glucagon-Like Peptide-1 Receptor

Figure 5

GLP-1R and PPAR-γ in NRK-52E cells with palmitic acid. (a, b) “” shows decreased PPAR-γ and GLP-1R in NRK-52E cells with 100 μM palmitic acid, compared to those without palmitic acid. (c, d) “” shows increased PPAR-γ and GLP-1R in NRK-52E cells with 100 μM palmitic acid and 50 μM emodin, compared to those with 100 μM palmitic acid but without emodin; Results in the figure show the interaction between PPAR-γ and GLP-1R promoter. (f) “” shows decreased GLP-1R in NRK-52E cells with 100 μM palmitic acid, 50 μM emodin, and 25 μM GW9662, compared to those with 100 μM palmitic acid and 50 μM emodin, but without GW9662. All results were repeated at least 3 times.

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