Mutation Profile Assessed by Next-Generation Sequencing (NGS) of Circulating Tumor DNA (ctDNA) in Chinese Lung Adenocarcinoma Patients: Analysis of Real-World Data

Table 4

Specific distribution of common gene mutations except for EGFR mutations.

Gene	Mutation	Number	Percentage (%)
ALK	EML4-ALK	8	5.26
	D1311E	1	0.66
	K1101N	1	0.66
	NT5C1B/MIR4757 break and rearrangement	1	0.66
PIK3CA	E545K	6	3.95
	H1047L	1	0.66
	P449L	1	0.66
	M1043I	1	0.66
	Q546K	1	0.66
KRAS	G12C	5	3.29
	G13D	2	1.32
	G12A	1	0.66
	G12D	1	0.66
	G12V	1	0.66
PTEN	S59X	1	0.66
	A126T	1	0.66
	R130X truncation	1	0.66
	V317	1	0.66
	A126T	1	0.66
	L247	1	0.66
HER2	Exon-20 insertion	2	1.32
	R143Q	1	0.66
MET	Amplification	3	1.97
NF1	W2317X truncation+Y489C	1	0.66
	S436fs	1	0.66
BRAF	V600E	2	1.32
ROS-1	ROS1-CD47 fusion	1	0.66
Total		50	32.9