Altered Genes and Biological Functions in Response to Severe Burns

Figure 4

Genes and signaling pathways that are persistently altered during severe burn. (a, b) Persistently differentially expressed genes (DEGs) in patients who (a) died or (b) survived in the CB group were clustered into persistently up- or downregulated genes. (c, d) The same analysis was performed for persistent DEGs in placebo (PB) patients who (c) died or (d) survived. Red represents upregulated genes, and blue represents downregulated genes. In the CB group, the signaling pathways with the (e) highest or (f) lowest activity during four burn stages are shown. Analogously, in the PB group, the signaling pathways with the (g) highest or (h) lowest activity during four burn stages are shown. Signaling pathway activity is represented on a color gradient from blue (lower) to red (higher). Subtype refers to S1-S4. (i) Levels of different immune cell types during burn response in patients treated with hydrocortisone (CB) or placebo (PB). A change from blue to red indicates a gradual increase in the number of cells. S1-S4 refer to before treatment administration, one day after treatment administration, 120 h after treatment administration, and 168 h after treatment administration.

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