A New Mathematical Model for Controlling Tumor Growth Based on Microenvironment Acidity and Oxygen Concentration

Figure 1

Physical structure of the model as a square lattice. (a) The considered tumor is composed of three layers: necrotic cells (dark gray layer), quiescent cells (middle shaded layer), and proliferating cells (dotted layer). The average radius of the tumor, necrotic layer, and the average thickness of the outer proliferating cancerous cells layer are shown by, , , and , respectively.