A New Mathematical Model for Controlling Tumor Growth Based on Microenvironment Acidity and Oxygen Concentration

Table 2

Summary of control parameters used in the simulations with their references.

Symbol	Description	Value	Units	Ref.
pH_thre_q	Critical pH: PC ➔ QC	6.4	—	[52]
pH_thre_Ne	Critical pH: QC ➔ NeC	6	—	[53]
O2_thre	O2 threshold value: PC ➔ QC	0.02	mMol	[54]
gl_thre	Glucose threshold value: PC ➔ QC	0.06	mMol	[54]
O2_thre2	O2 threshold value: QC ➔ NeC	O2_thre/2	mMol	—
gl_thre2	Glucose threshold value: QC ➔ NeC	gl_thre/2	mMol	—
Do2	O2 diffusion coef.		cm^2 s^-1	[55]
Dgl	Glucose diffusion coef.		cm^2 s^-1	[56, 57]
DGf	Growth factor diffusion coef.		cm^2 h^-1	[48]
DIf	Inhibition factor diffusion coef.		cm^2 h^-1	[48]
DH	H^+ diffusion coef.		cm^2 s^-1	[57, 58]
Cr_o2	Base consumption rate of O2		Mol.cells^-1.s^-1	[59, 60]
Cr_gl	Base consumption rate of gl		Mol.cells^-1.s^-1	[48, 61]
Cr_Gf	Base consumption rate of Gf	0.5	cm^3.h^-1	[48]
Cr_If	Base production rate of if	1	cm^3.h^-1	[48]
Cr_H	Base production rate of H^+		Mol.cells^-1.s^-1	[42, 62]