Effects of Curcumin on Aging: Molecular Mechanisms and Experimental Evidence

Figure 1

Mechanisms by which curcumin modulate aging process and senescence. Curcumin inhibited OS-stimulated p38MAPK activation, Aβ fibril aggregation, and expression of age-associated genes (dInR, ATTD, Def, CecB, DptB, mth, thor, InR, and JNK), although curcumin induced eNOS, NO, Sirt1, HO-1, and UCP2 expression. Curcumin also mitigates the SASP and its aging-induction consequences of senescent cell. Abbreviations: Aβ: amyloid-β; eNOS: endothelial nitric-oxide synthase; HO-1: hemeoxygenase-1; mTORC 1: mammalian/mechanistic target of rapamycin complex 1; NO: nitric oxide; ROS: reactive oxygen species; SASP: senescence-associated secretory phenotype; Sirt: sirtuins; UCP2: uncoupling protein 2.