BioMed Research International

Research Article

Integrated MicroRNA Expression Profile Reveals Dysregulated miR-20a-5p and miR-200a-3p in Liver Fibrosis

Table 3

Hub genes identified in the PPI interaction.
Gene symbolDescriptionDegree
Upregulated miRNA
 TP53Tumor protein P53136+++
 EGFREpidermal growth factor receptor106———
 PTENPhosphatase and tensin homolog105++—
 JUNJun proto-oncogene93+——
 VEGFAVascular endothelial growth factor A89———
 KRASKRAS proto-oncogene, GTPase87+——
 STAT3Signal transducer and activator of transcription 386+——
 CTNNB1Catenin beta 185———
 NOTCH1Notch receptor 185———
 EP300E1A binding protein p30082+—+
Downregulated miRNA
 TP53Tumor protein P53235+++
 UBCUbiquitin C191———
 RPS27ARibosomal protein S27a184———
 MYCMYC proto-oncogene, bHLH transcription factor175+—+
 HSP90AA1Heat shock protein 90 alpha family class A member 1153———
 MAPK1Mitogen-activated protein kinase 1144+——
 PTENPhosphatase and tensin homolog134++—
 CCND1Cyclin D1125+++
 HSPA8Heat shock protein family A (Hsp70) member 8124———
 VEGFAVascular endothelial growth factor A119———
: hepatitis B; : p53 signaling pathway; : cell cycle. “+” and “-,” respectively, indicate genes can and cannot be found in corresponding KEGG pathways.