[Retracted] Synthesis, Characterization, and Specific Localization of Mitochondrial-Targeted Antioxidant Peptide SS31 Probe

Figure 5

(a) Phase-contrast micrographs of 661W cells following treatment with 100 nM SS31 before 100 μM H₂O₂ treatment; the number of shrunken and dead cells was decreased following SS31 treatment. (b) The quantitative data of the protective effect of SS31 (, ; significantly different from control; ^#significantly different from the H₂O₂ group). (c) 661W cell activity was investigated using MTT assay. The cell viability increased following treatment with 10 nM, 100 nM, and 1 μM SS31, respectively. Significantly different from control; ^#significantly different from H₂O₂ treatment (; ). (d) The assays demonstrated an increase in LDH release at 100 μM H₂O₂ exposure and a reduction in LDH release by SS31 pretreatment. The data are expressed as the percentage permeability of LDH through the cell membrane of 661W cells with standard errors.

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