Research Article

[Retracted] Increased EHHADH Expression Predicting Poor Survival of Osteosarcoma by Integrating Weighted Gene Coexpression Network Analysis and Experimental Validation

Table 3

Functional and KEGG pathway enrichment analysis of EHHADH and its coexpressed genes. Top 3 GO terms and KEGG terms with were selected.

TermNameCountFDR

A, biological processes
GO: 1904224Negative regulation of glucuronosyltransferase activity55.78-07
GO: 2001030Negative regulation of cellular glucuronidation55.78-07
GO: 0045922Negative regulation of fatty acid metabolic process55.78-07
B, molecular functions
GO: 0001972Retinoic acid binding58.33-05
GO: 0015020Glucuronosyltransferase activity58.46-05
GO: 0016758Transferase activity, transferring hexosyl groups58.46-05
C, cellular components
GO: 0016324Apical plasma membrane106.69-06
GO: 0070062Extracellular exosome237.17-05
GO: 0005887Integral component of plasma membrane139.71-03
D, KEGG pathways
hsa00983Drug metabolism—other enzymes74.20-06
hsa00982Drug metabolism—cytochrome P45072.28-05
hsa00980Metabolism of xenobiotics by cytochrome P45072.51-05
hsa05204Chemical carcinogenesis72.51-05
hsa01100Metabolic pathways192.51-05
hsa00053Ascorbate and aldarate metabolism58.08-05
hsa00040Pentose and glucuronate interconversions51.58-04
hsa00860Porphyrin and chlorophyll metabolism53.67-04
hsa00140Steroid hormone biosynthesis51.17-03
hsa00830Retinol metabolism51.55-03
hsa00770Pantothenate and CoA biosynthesis32.01-02