Research Article
[Retracted] Increased EHHADH Expression Predicting Poor Survival of Osteosarcoma by Integrating Weighted Gene Coexpression Network Analysis and Experimental Validation
Table 3
Functional and KEGG pathway enrichment analysis of EHHADH and its coexpressed genes. Top 3 GO terms and KEGG terms with
were selected.
| Term | Name | Count | FDR |
| A, biological processes | GO: 1904224 | Negative regulation of glucuronosyltransferase activity | 5 | 5.78-07 | GO: 2001030 | Negative regulation of cellular glucuronidation | 5 | 5.78-07 | GO: 0045922 | Negative regulation of fatty acid metabolic process | 5 | 5.78-07 | B, molecular functions | GO: 0001972 | Retinoic acid binding | 5 | 8.33-05 | GO: 0015020 | Glucuronosyltransferase activity | 5 | 8.46-05 | GO: 0016758 | Transferase activity, transferring hexosyl groups | 5 | 8.46-05 | C, cellular components | GO: 0016324 | Apical plasma membrane | 10 | 6.69-06 | GO: 0070062 | Extracellular exosome | 23 | 7.17-05 | GO: 0005887 | Integral component of plasma membrane | 13 | 9.71-03 | D, KEGG pathways | hsa00983 | Drug metabolism—other enzymes | 7 | 4.20-06 | hsa00982 | Drug metabolism—cytochrome P450 | 7 | 2.28-05 | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 7 | 2.51-05 | hsa05204 | Chemical carcinogenesis | 7 | 2.51-05 | hsa01100 | Metabolic pathways | 19 | 2.51-05 | hsa00053 | Ascorbate and aldarate metabolism | 5 | 8.08-05 | hsa00040 | Pentose and glucuronate interconversions | 5 | 1.58-04 | hsa00860 | Porphyrin and chlorophyll metabolism | 5 | 3.67-04 | hsa00140 | Steroid hormone biosynthesis | 5 | 1.17-03 | hsa00830 | Retinol metabolism | 5 | 1.55-03 | hsa00770 | Pantothenate and CoA biosynthesis | 3 | 2.01-02 |
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