Research Article

An Ensemble Learning-Based Method for Inferring Drug-Target Interactions Combining Protein Sequences and Drug Fingerprints

Table 6

The comparison between LPQ and PHOG with rotation forest in terms of accuracy (Acc.), precision (Pre.), sensitivity (Sen.), specificity (Spec.), and Matthews correlation coefficient (MCC) on four types of benchmark data sets.

Data setMethodAcc. (%)Prec. (%)Sen. (%)Spec. (%)MCC (%)

EnzymeLPQ+RF
PHOG+RF
Ion ChannelLPQ+RF
PHOG+RF
GPCRsLPQ+RF
PHOG+RF
Nuclear receptorLPQ+RF
PHOG+RF