Circulating IL-17 Level Is Positively Associated with Disease Activity in Patients with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis
Table 1
Characteristics of the incorporated studies.
Study
Country
Sample size (Ac/In-ac)
Female (%) Ac/In-ac
Age (y) Ac/In-ac
Disease duration (y) Ac/In-ac
IL-17 (pg/ml) Ac/In-ac
Detection methods
Definition of active SLE
Quality
Abo-Shanab et al. (2020)
Egypt
50
100
ELISA
NA
0.558
2
Abou Ghanima et al. (2012)
Egypt
30 (15/15)
93.3/86.7
ELISA
0.661
3
Cavalcanti et al. (2017)
Brasil
51 (26/25)
92
Cytometric Bead Array Human Th1/Th2/Th17 Cytokine kit
0.242
3
Chen et al. (2010)
China
60
100
18-49$
NA
ELISA
SLEDAI>12 (severe)
0.549
2
Elvira et al. (2020)
Indonesia
68 (34/34)
100
17.6% (≤1 yr)
ELISA
NA
2
Galil et al. (2015)
Egypt
72 (30/42)
100
ELISA
SLEDAI-2 K ≥4 and have active lupus nephritis
0.322
2
Hammad et al. (2017)
Egypt
42 (42/0)
81.0/0
ELISA
NA
0.824
2
Huang et al. (2019)
China
80 (37/43)
70.3/67.4
NA
ELISA
0.648
2
Jin et al. (2018)
China
55
94.6
ELISA
(more active)
-0.005
2
Lozovoy et al. (2014)
Brazil
123 (53/70)
90.6/94.3
NA
NA
Decreased C3 (<90 mg/dL) and/or decreased C4 (<10 mg/dL) and/or positive anti-double-stranded DNA (anti-dsDNA; titre 1/10).
NA
3
Madkour et al. (2015)
Egypt
57
94.7
ELISA
NA
0.130
1
Mohammadi et al. (2019)
Iran
40
100
NA
NA
NA
ELISA
NA
-0.238
1
Mok et al. (2010)
China
70 (36/34)
92.9
14.8/14.8#
ELISA
-0.178
2
Nakhjavani et al. (2019)
Iran
50 (44/6)
80
NA
ELISA
0.692 (-no LN) 0.845 (-LN)
2
Nordin et al. (2019)
Malaysia
120 (56/64)
89.2
41.9 ± 12.5
11.8 ± 7.2
42.88 ± 13.05/35.99 ± 8.99
ELISA
Modified SLEDAI-2 K ≥1
0.447
2
Rana et al. (2012)
India
40
85
ELISA
0.447
2
Raymond et al. (2019)
Norway
100
87
49#
NA
NA
ELISA
0.039
3
Robak et al. (2013)
Poland
60 (28/32)
91.7
ELISA
NA
2
Salazar-Camarena et al. (2019)
Mexico
36 (23/13)
100
Invitrogeńs Novex human Th1/Th2/Th17 Magnetic 10-Plex Panel assay
0.544
2
Talaat et al. (2015)
Egypt
60 (32/28)
93.3
ELISA
NA
2
Wong et al. (2008)
China
40 (3/37)
97.5
ELISA
0.374
2
Yang et al. (2013)
China
65 (45/20)
91.1/90
ELISA
SLEDAI≥5
0.211
2
Yao et al. (2016)
China
50 (36/14)
90
NA
ELISA
0.229
2
Yin et al. (2014)
China
79
96.2
MILLIPLEX MAP human cytokine detection kit
-0.117 ()
2
Zhao et al. (2010)
China
57
96.5
NA
NA
ELISA
(more active)
0.173
2
Zhou et al. (2018)
China
77
96.1
ELISA
0.313
2
,, and . Value presented as number, percentage, mean (#), range ($), or (SD). Abbreviation: Ac: active; In-ac: inactive; SLE: systemic lupus erythematosus; ELISA: enzyme-linked immunosorbent assay; SLEDAI-2K: systemic lupus erythematosus disease activity index 2000; NA: not applicable; SLEDAI: systemic lupus erythematosus disease activity index; LN: lupus nephritis. Quality was measured by modified Newcastle–Ottawa Scale (M-NOS).
