[Retracted] FXYD6 Regulates Chemosensitivity by Mediating the Expression of Na+/K+-ATPase α1 and Affecting Cell Autophagy and Apoptosis in Colorectal Cancer

Figure 1

FXYD6 was silenced in chemoresistance colorectal cancer and related to chemosensitivity. (a) FXYD6 expression was analyzed in the resistant and sensitive groups treated by Oxa or Iri from GSE69657 and GSE3964. The green box and orange box indicated the resistant group (R) and sensitive group (S), respectively. (b) Statistical analysis of FXYD6 expression data in CRC from TCGA DataSet; the purple box indicated the normal tissue sample; the red box indicated the primary tumor tissue sample. (c) FXYD6 expression was measured in cancer tissues and relative adjacent tissues from five CRC patients by RT-PCR. (d) Expression of FXYD6 was detected by RT-PCR in the different CRC cell lines and normal cell line HCoEpic. (e) The upper panel showed the western blotting of FXYD6 in the different CRC cell lines and normal cell line HCoEpic; β-actin was used as the internal control. The lower panel was the quantification of FXYD6 by the ImageJ program. (f) FXYD6 expression was tested in CRC cell lines SW620 and SW620/Iri by RT-PCR. (g) The left panel showed the protein levels of FXYD6 in SW620 and SW620/Iri cells by western blotting; β-actin was used as the internal control. The right panel was the quantification of FXYD6 by the ImageJ program.

(a)

(b)

(c)

(d)

(e)

(f)

(g)