Peptidome Analysis of Pancreatic Tissue Derived from T1DM Mice: Insights into the Pathogenesis and Clinical Treatments of T1DM

Table 1

Differentially expressed peptides located in function domain based on Uniport and Pfam database.

Protein	Peptide sequence	Location	Domain location	Domain description
Downregulated peptides
PDIA2	VDGPAEPELT	103-112	29-155	Thioredoxin 1
INS1	ELGGSPGDL	67-75	28-107	Insulin
INS1	ELGGSPGDLQTLA	67-79	28-107	Insulin
INS2	GAGDLQTLAL	73-82	28-109	Insulin
AMY2	QNDWIGPPN	366-374	26-410	Aamy
INS2	DPQVAQLELGGGPGAGDLQT	60-79	28-109	Insulin
INS2	ELGGGPGAGDLQT	67-79	28-109	Insulin
INS2	LELGGGPGAGDLQT	66-79	28-109	Insulin
INS2	VEDPQVAQLELGGGPGAGDLQT	58-79	28-109	Insulin
INS2	ELGGGPGAGDLQTL	67-80	28-109	Insulin
NUPR1	EAAANTNRPSPGGHE	49-63	21-77	Phospho-p8
IAPP	SSNNLGPVLPPTNVGSNTY	56-74	29-79	Calcitonin
INS2	EDPQVAQLELGGGPGAGDLQ	59-78	28-109	Insulin
INS2	EDPQVAQLELGGGPGAGDLQT	59-79	28-109	Insulin
INS2	VEDPQVAQLELGGGPGAGDLQ	58-78	28-109	Insulin
INS2	ELGGGPGAGDLQ	67-78	28-109	Insulin
INS1	EVEDPQVEQLELGGSPGD	57-74	28-107	Insulin
Hbbt1	LLVVYPWTQR	36-45	2-251	Globin
INS2	VEDPQVAQLELGGGPGAGD	58-76	28-109	Insulin
INS2	EDPQVAQLELGGGP	59-72	28-109	Insulin
INS2	QLELGGGP	65-72	28-109	Insulin
INS2	EDPQVAQLELGGGPGAGD	59-76	28-109	Insulin
INS2	GGPGAGDLQTL	70-80	28-109	Insulin
Eif4a1	NTSIEEMPLN	392-401	245-406	Helicase C-terminal
UB2L3	VNDPQPEHPL	112-121	2-149	UBC core
Rplp0	ADPSAFAAAAPA	275-281	231-316	Ribosomal-60s
INS2	QLELGGGPGAGDL	65-77	28-109	Insulin
INS2	LGGGPGAGDL	68-77	28-109	Insulin
INS2	GGGPGAGDLQT	69-79	28-109	Insulin
Actb	VAPEEHPVLLTEAPLNPK	96-113	2-375	Actin
IAPP	GPVLPPTNVGSNTY	61-74	29-79	Calcitonin
INS2	ELGGGPGAGDL	67-77	28-109	Insulin
AMY2	LNPNNREFPAVP	134-145	26-410	Aamy
Ruvbl1	AQTEGINISEEALNHLGEIGTK	379-400	374-439	TIP49-c
MDH1	GVISDGNSYGVPDD	270-283	156-331	Ldh_1_N
B2m	AHTEFTPTETDT	86-97	25-114	Ig-like
Upregulated peptides
Actb	DIAALVVDN	4-12	2-375	Actin
Rpsa	APTAQATEWVGATTE	279-293	202-295	40S_SA_C
Hsp90b1	SLTDENALAGNEELT	119-133	96-255	HATPase-c
Tuba1a	DLEPTVIDEVRTGT	69-82	3-214	Tubulin
Rbm3	DYSGRSQGGYD	131-141	81-154	Disordered
Cct7	GVDINNENIADN	476-487	32-524	Cpn60_TCP1
ERP27	DLEIPIVS	66-73	39-152	Thioredoxin
UBN2	DETDPFIDNSEA	196-207	180-231	HUN
Ptma	SDAAVDTSSEITTKD	62-76	62-170	Prothymosin
AMY2	SAEDPFIAIHADS	494-506	419-507	Aamy_C
Atp5f1b	EVAQHLGES	98-106	63-129	ATP-synt_ab_N
P4hb	DRTVIDYNGE	453-462	348-477	Thioredoxin