Potential Differences in the Cardiometabolic Risk Profile of Patients with Psoriatic Disease according to Their HLA-C06 Status

Table 2

Distribution of variables between HLA-C06-positive versus negative subjects.

Variable	HLA-C06 positive; : 160	HLA-C06 negative; : 240	values
Age (yrs), mean (SD)	43.3 (13.8)	48 (15)	<0.05
Age (yrs) at psoriasis onset, mean (SD)	22 (14.8)	32.6 (17.6)	<0.05
Disease duration (yrs), mean (SD)	19.2 (14.3)	15.3 (14.7)	NS
Men, (%)	88 (55)	127 (53)	NS
Women, (%)	72 (45)	113 (47)	NS
PsA, (%)	34 (21.3)	59 (24.6)	NS
Psoriasis family history, (%)	88 (55)	80 (33.3)	<0.05
, (%)	80 (50)	80 (33.3)	<0.05
Total cholesterol, mean (SD)	203.2 (41.8)	206.7 (43.4)	NS
HDL-C, mean (SD)	54.1 (15.4)	53.7 (14.8)	NS
LDL-C, mean (SD)	125.6 (36.7)	129.5 (36)	NS
TG, mean (SD)	125.1 (75.9)	128.7 (86.5)	NS
Glucose, mean (SD)	97.5 (32.6)	103.8 (33.9)	NS
BMI, mean (SD)	27 (4.4)	28.2 (4.8)	<0.05
Waist perimeter (cm), mean (SD)	94.4 (13.7)	98.3 (13.8)	<0.05
Hypertension, (%)	22 (13.8)	58 (24.2)	<0.05
Dyslipidemia, (%)	21 (13.1)	43 (17.9)	NS
Obesity, (%)	42 (26.3)	78 (32.5)	NS
Smoker, (%)	32 (20)	40 (16.7)	NS
CHD, (%)	8 (5)	17 (7.1)	NS
Topical/photo therapy, (%)	48 (30)	132 (55)	<0.05
Systemic treatment, (%)	88 (55)	160 (66.7)	NS
Biologics, (%)	90 (56.3)	82 (34.2)	<0.05

Yrs: years; SD: standard deviation; : number; PsA: psoriatic arthritis; PASI: psoriasis area and severity index; BMI: body mass index; CHD: coronary heart disease; HDL-C (mg/dl): high-density lipoprotein cholesterol; LDL-C (mg/dl): low-density lipoprotein cholesterol; TG (mg/dl): triglycerides. These values refer to the first visit to the clinic; Student’s -test; chi-square test; Fisher’s exact test.