Long Noncoding RNA LIFR-AS1: A New Player in Human Cancers

Table 1

Functional characterization of LIFR-AS1 in various cancers.

Cancer type	Expression	Cell line	Role	Biological function	Related genes and protein	Reference
Glioma	Downregulated	U251, A172	Suppressor	Suppress proliferation, migration, and invasion and promote apoptosis	miR-4262 increased,	[18]
					NF-κB pathway activated
					p-NF-κB p65 and IκBα activated
Breast cancer	Downregulated	MDA-MB-415, MCF7	Suppressor	Suppress proliferation, colony formation, migration, and invasion	miR-197-3p increased, Sufu decreased	[20]
					MAPK pathway activated
Thyroid cancer	Upregulated	MDA-T32, MDA-T68	Oncogenic	Promote proliferation, migration, invasion,	Cyclin B1 increased, CDK1 increased	[19]
				Promote cell cycle	MMP2 increased, MMP9 increased
Lung cancer	Downregulated	A549, H1299, PC-9, H1975	Suppressor	Suppress migration and invasion	miR-942-5p increased, ZNF471 decreased	[22]
Gastric cancer	Upregulated	BSG823, BGC803	Oncogenic	Promote proliferation, migration, and invasion and suppress apoptosis	miR-29a-3p decreased, COL1A2 increased	[23, 24]
	Downregulated	MKN45, AGS	Suppressor	Suppress proliferation, migration, and invasion	miR-4698 increased, MTUS1 decreased, MEK/ERK pathway inhibited	[25]
Colorectual cancer	Upregulated	HCT116	Oncogenic	Promote proliferation and suppress apoptosis	miR-29a decreased, TNFAIP3, miR-182 decreased, miR-106a decreased, miR-372 decreased, miR-144 decreased, miR-206 decreased	[29–31]
Osteosarcoma	Upregulated	U20S, 143B	Oncogenic	Promote proliferation and invasion and suppress apoptosis	miR-29a increased, NFIA decreased	[42]