Potential Factors Predicting Histopathologically Upgrade Discrepancies between Endoscopic Forceps Biopsy of the Colorectal Low-Grade Intraepithelial Neoplasia and Endoscopic Resection Specimens

Table 2

Baseline characteristics of the concordant group and the upgrade group disease after endoscopic resection.

Characteristics	Upgrade group ()	Concordant group ()	value
Age/y, median (IQR)	59 (48.75, 67)	58 (50, 65)	0.449
Female, (%)	69 (42.6)	263 (34.8)	0.061
Past medical history, (%)
HT	48 (29.6)	156 (20.6)	0.012
DM	21 (13.0)	71 (9.4)	0.170
NSAID	22 (13.6)	29 (3.8)	<0.001
Colorectal polyps	5 (3.1)	27 (3.6)	0.76
FAP	1 (0.6)	2 (0.3)	0.442
CRC	8 (4.9)	48 (6.3)	0.496
Lack of standardization of EFB number, (%)	102 (63.0)	217 (28.7)	0.001
EFB diagnosis, (%)			<0.001
Tubular	126 (77.8)	663 (87.7)
Tubulovillous	25 (15.4)	77 (10.2)
Villous	11 (6.8)	16 (2.1)
Postoperative pathological diagnosis, (%)
Tubular adenoma	—	712 (77.6)
Tubulovillous adenoma	—	34 (3.7)
Villous adenoma	—	10 (1.1)
HGD	114 (12.4)	—
Intramucosal carcinoma	33 (3.6)	—
Submucosal adenocarcinoma	10 (1.1)	—
Advanced adenocarcinoma	5 (0.5)
Maximum diameter of the target adenoma/cm, median (IQR)	2.44 (1.5, 3)	1.59 (1, 2)	<0.001
Lobulated pattern, (%)	85 (52.5)	107 (14.2)	<0.001
Erythema, (%)	127 (78.4)	334 (44.2)	<0.001
Erosion, (%)	69 (42.6)	33 (4.4)	<0.001
Surface unevenness, (%)	80 (49.4)	69 (9.1)	<0.001
Blood biochemistry, median (IQR)
TG, mmol/L	1.14 (0.80, 1.63)	1.27 (0.89, 1.84)	0.025
TC, mmol/L	4.33 (3.73, 5.08)	4.6 (4.03, 5.24)	0.002
HDL, mmol/L	1.27 (1.03, 1.49)	1.25 (1.05, 1.52)	0.742
LDL, mmol/L	2.56 (2.04, 3.10)	2.79 (2.25, 3.30)	0.001
Shape pattern, (%)			0.547
Yamada I+II	79 (48.8)	349 (46.2)
Yamada III+IV	83 (51.2)	407 (53.8)
LST, (%)	5 (3.1)	37 (4.9)	0.318
Multiple colorectal polyps	73 (45.1)	293 (38.8)	0.137
Distal location of the target adenoma, (%)	143 (88.3)	578 (76.5)	<0.001

HT: hypertension; DM: diabetes mellitus; NSAID: nonsteroidal anti-inflammatory drug; FAP: familial adenomatous polyposis; CRC: colorectal cancer; HGD: high-grade dysplasia; TG: triglyceride; TC: total cholesterol; HDL: high-density lipoprotein; LDL: low-density lipoprotein.