Diagnostic Value of Serum Chitinase-3-Like Protein 1 for Liver Fibrosis: A Meta-analysis

Table 1

Characteristics of the included studies ().

First author	Year	Country	Reference method	Test method	Male, (%)	Average age, y	Scoring system	Aetiology
Huang[46]	2015	China	Liver biopsy	ELISA	NA	24.5	Scheuer	HBV
Kumagai [47]	2016	Japan	Liver biopsy	ELISA	59 (44.0)	65.8	METAVIR	Mixed
Mehta[26]	2008	America	Liver biopsy	ELISA	46 (62.0)	52.0	Ishak	HCV
Mo [48]	2020	China	Liver biopsy	ELISA	257 (55.8)	40.9	Scheuer	Mixed
Pan [49]	2021	China	Liver biopsy	Fluorescence immunochromatography	26 (76.5)	48.5	Scheuer	Mixed
Saitou[50]	2005	Japan	Liver biopsy	ELISA	62 (56.9)	51.4	METAVIR	HCV
Tran [51]	2000	France	Liver biopsy	ELISA	106 (72.6)	49.2	NA	Mixed
Wu [52]	2020	China	Liver biopsy	ELISA	90 (67.2)	39.0	METAVIR	HBV
Xiao [53]	2011	China	Liver biopsy	ELISA	80 (44.4)	39.8	HAI	HBV
Yang [54]	2019	China	Liver biopsy	ELISA	86 (50.0)	39.0	METAVIR	HBV
Yu [55]	2017	China	Liver biopsy	ELISA	172 (76.1)	52.2	NA	Mixed

ELISA: enzyme-linked immunoassay; HBV: hepatitis B virus; HCV: hepatitis C virus; NA: not available; HAI: histological activity index.