TY - JOUR
A2 - Deniz, Nahide Gulsah
AU - Pang, Qi Qi
AU - Kim, Ji-Hyun
AU - Choi, Ji Myung
AU - Song, Jia-Le
AU - Lee, Sanghyun
AU - Cho, Eun Ju
PY - 2022
DA - 2022/01/07
TI - Cirsium japonicum var. Maackii Improves Cognitive Impairment under Amyloid Beta25-35-Induced Alzheimer’s Disease Model
SP - 4513998
VL - 2022
AB - Abnormal production and degradation of amyloid beta (Aβ) in the brain lead to oxidative stress and cognitive impairment in Alzheimer’s disease (AD). Cirsium japonicum var. maackii (CJM) is widely used as an herbal medicine and has antibacterial and anti-inflammatory properties. This study focused on the protective effect of the ethyl acetate fraction from CJM (ECJM) on Aβ25-35-induced control mice. In the T-maze and novel object recognition test, ECJM provided higher spatial memory and object recognition compared to Aβ25-35 treatment alone. In the Morris water maze test, ECJM-administered mice showed greater learning and memory abilities than Aβ25-35-induced control mice. Additionally, ECJM-administered mice experienced inhibited lipid peroxidation and nitric oxide production in a dose-dependent manner. The present study indicates that ECJM improves cognitive impairment by inhibiting oxidative stress in Aβ25-35-induced mice. Therefore, CJM may be useful for the treatment of AD and may be a potential material for functional foods.
SN - 2314-6133
UR - https://doi.org/10.1155/2022/4513998
DO - 10.1155/2022/4513998
JF - BioMed Research International
PB - Hindawi
KW -
ER -