TY - JOUR A2 - Deniz, Nahide Gulsah AU - Pang, Qi Qi AU - Kim, Ji-Hyun AU - Choi, Ji Myung AU - Song, Jia-Le AU - Lee, Sanghyun AU - Cho, Eun Ju PY - 2022 DA - 2022/01/07 TI - Cirsium japonicum var. Maackii Improves Cognitive Impairment under Amyloid Beta25-35-Induced Alzheimer’s Disease Model SP - 4513998 VL - 2022 AB - Abnormal production and degradation of amyloid beta (Aβ) in the brain lead to oxidative stress and cognitive impairment in Alzheimer’s disease (AD). Cirsium japonicum var. maackii (CJM) is widely used as an herbal medicine and has antibacterial and anti-inflammatory properties. This study focused on the protective effect of the ethyl acetate fraction from CJM (ECJM) on Aβ25-35-induced control mice. In the T-maze and novel object recognition test, ECJM provided higher spatial memory and object recognition compared to Aβ25-35 treatment alone. In the Morris water maze test, ECJM-administered mice showed greater learning and memory abilities than Aβ25-35-induced control mice. Additionally, ECJM-administered mice experienced inhibited lipid peroxidation and nitric oxide production in a dose-dependent manner. The present study indicates that ECJM improves cognitive impairment by inhibiting oxidative stress in Aβ25-35-induced mice. Therefore, CJM may be useful for the treatment of AD and may be a potential material for functional foods. SN - 2314-6133 UR - https://doi.org/10.1155/2022/4513998 DO - 10.1155/2022/4513998 JF - BioMed Research International PB - Hindawi KW - ER -